By: Philip G. Janicak, M.D.; John P. O’Reardon, M.D.; Shirlene M. Sampson, M.D.; Mustafa M. Husain, M.D.; Sarah H. Lisanby, M.D.; Jeffrey T. Rado, M.D.; Karen L. Heart, M.B.A.; and Mark A. Demitrack, M.D.
Background: Transcranial magnetic stimulation (TMS) has demonstrated efficacy in the treatment of major depressive disorder; however, prior studies have provided only partial safety information. We examined the acute efficacy of TMS in a randomized sham controlled trial, under open label conditions, and its durability of benefit.